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Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated fatty liver disease (MAFLD), is spectrum of diseases that ranges from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). Invasive liver biopsy continues to be the gold standard for diagnosing NASH through the histopathological assessment of liver steatosis, ballooning and lobular inflammation. However, this method does […]

TOPLINE: Significant associations were found between readmission with diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D) and both substance abuse and incarceration.  METHODOLOGY: At a large county hospital in Texas, an electronic health records query for patients with T1D admitted with a DKA diagnosis between 2019 and 2021 identified 243 with at least […]

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn’s disease before noticeable symptoms develop. Led by the Department of Genetics and Genomic […]

The United States has a maternal mortality crisis. In 2021, 1205 women in this country died of pregnancy-related causes, up from 861 in 2020. Meanwhile, an estimated 80% of these deaths are preventable. Some experts say follow-up care in the year after delivery is critical to monitor for any complications, and primary care clinicians play […]

A European consortium of 19 partners has been awarded over €6.5M by the European Union to study psilocybin to treat psychological distress in people with progressive incurable illnesses requiring palliative care. This is the first time the EU has funded a multi-site clinical study into psychedelic-assisted therapy. The randomized controlled trial (RCT) PsyPal, coordinated by […]

A recent Scientific Reports study assessed whether clinically derived measures of heart rate variability (HRV) and blood pressure variability (BPV) are associated with the manifestation of Alzheimer’s Disease and Related Dementias (ADRD). Study: Blood pressure variability supersedes heart rate variability as a real-world measure of dementia risk. Image Credit: Andrii Vodolazhskyi / Shutterstock Background Previous studies have established a […]

TOPLINE: In patients with advanced Parkinson’s disease (PD), quality of life (QoL) remains stable at 5 years in those who receive deep brain stimulation of the subthalamic nucleus (STN-DBS) vs standard-of-care medical treatment (MED), results of a nonrandomized quasi-experimental trial showed. METHODOLOGY: Researchers applied propensity score matching to 108 patients with advanced PD from the […]

The researchers of a recent study published in Nature Metabolism investigated the relationship between milk consumption and type 2 diabetes (T2D) among lactase non-persistent (LNP) individuals. Study: Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes. Image Credit: Yurii_Yarema/Shutterstock.com Background Cow’s milk is part of the human diet; […]

New data from the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) suggest that a daily multivitamin may help protect the aging brain. However, at least one expert has concerns about the study’s methodology and, as a result, the interpretation of its findings.  The meta-analysis of three separate cognition studies provides “strong and consistent evidence that […]

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer. But PD-1 functions can vary between different cell and cancer types, either promoting or suppressing disease progression. Merkel cell carcinoma (MCC), a […]