A recent Scientific Reports study assessed whether clinically derived measures of heart rate variability (HRV) and blood pressure variability (BPV) are associated with the manifestation of Alzheimer’s Disease and Related Dementias (ADRD). Study: Blood pressure variability supersedes heart rate variability as a real-world measure of dementia risk. Image Credit: Andrii Vodolazhskyi / Shutterstock Background Previous studies have established a […]
TOPLINE: In patients with advanced Parkinson’s disease (PD), quality of life (QoL) remains stable at 5 years in those who receive deep brain stimulation of the subthalamic nucleus (STN-DBS) vs standard-of-care medical treatment (MED), results of a nonrandomized quasi-experimental trial showed. METHODOLOGY: Researchers applied propensity score matching to 108 patients with advanced PD from the […]
The researchers of a recent study published in Nature Metabolism investigated the relationship between milk consumption and type 2 diabetes (T2D) among lactase non-persistent (LNP) individuals. Study: Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes. Image Credit: Yurii_Yarema/Shutterstock.com Background Cow’s milk is part of the human diet; […]
New data from the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) suggest that a daily multivitamin may help protect the aging brain. However, at least one expert has concerns about the study’s methodology and, as a result, the interpretation of its findings. The meta-analysis of three separate cognition studies provides “strong and consistent evidence that […]
Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer. But PD-1 functions can vary between different cell and cancer types, either promoting or suppressing disease progression. Merkel cell carcinoma (MCC), a […]
The US Food and Drug Administration (FDA) has added a boxed warning to the label of the osteoporosis drug denosumab (Prolia) about increased risk for severe hypocalcemia in patients with advanced chronic kidney disease (CKD). Denosumab is a monoclonal antibody, indicated for the treatment of postmenopausal women with osteoporosis who are at increased risk for […]
It is now well documented that the coronavirus outbreak triggered a global health crisis. In this study, researchers wanted to know whether blood-brain barrier impairment contributed to the development of neurological problems during COVID-19 progression, and to what extent. The blood-brain barrier is a filtering mechanism of the capillaries that carry blood to the brain […]
Manufacturers of diabetes drugs that have also become popular for weight loss raised their medication prices at the start of 2024. Novo Nordisk, which makes Ozempic, and Eli Lilly, which sells Mounjaro, increased drug costs during the first half of January, according to an analysis for The Wall Street Journal by 46brooklyn Research, a nonprofit […]
Tumors constantly shed DNA from dying cells, which briefly circulates in the patient’s bloodstream before it is quickly broken down. Many companies have created blood tests that can pick out this tumor DNA, potentially helping doctors diagnose or monitor cancer or choose a treatment. The amount of tumor DNA circulating at any given time, however, […]
A pediatrician warns parents not to give aspirin to their sick baby and points to the warning on the label. Silicone breast implants are heavily restricted. Medical residents now get a small break in their long hours. The above scenarios are spokes in a wheel of public service. The hub of that wheel was Sidney […]