In a recent study published in BMJ, researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied (via a surrogate biomarker) suppression of phosphodiesterase 5 (PDE5), a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior. Study: A drug target for erectile dysfunction to help improve fertility, sexual […]

The European Commission has granted approval to avapritinib (Ayvakit) to address moderate to severe symptoms in adult patients with indolent systemic mastocytosis (ISM) who are inadequately managed by current symptomatic treatments. This marks the first approved therapy for individuals with the condition in Europe. ISM is a rare blood disorder characterized by an abnormal build-up […]

San Francisco — In the first randomized controlled trial using the TriClip Transcatheter Tricuspid Valve Repair system (Abbott) for transcatheter edge-to-edge repair (TEER) of the tricuspid valve in patients with severe tricuspid regurgitation (TR), patients showed sustained TR reduction and improvements in quality of life at 1 year as well as safety at 30 days.  […]

In a recent study published in Scientific Reports, researchers used a convolutional neural network (CNN) to automate lagophthalmos diagnosis. Study: Diagnosing lagophthalmos using artificial intelligence. Image Credit: Joyseulay/Shutterstock.com Background Lagophthalmos is characterized by an inadequate or aberrant eyelid closure, which increases the risk of corneal ulcers and blindness. It is a frequent symptom of many diseases and […]

Changes in tissue thickness in the back of the eye can correlate with worsening or improvement of renal problems and could help predict who will have worsening of kidney function, a new analysis report finds.  The research, published in the journal Nature Communications, is the first to show an association between chronic kidney disease (CKD) and […]

In a recent study published in the journal Open Forum Infectious Diseases, researchers investigated COVID-19’s impact on severe maternal morbidity (SMM), potentially lethal complications that occur during the time of childbirth. They used declassified data from over 93,600 deliveries between March 2020 and July 2021 and found that risks, particularly those of adult respiratory distress […]

SAN DIEGO — In the real world, outcomes for patients with multiple myeloma who received standard regimens were dramatically worse than those reported in clinical trials, a new study found.  The analysis, which included nearly 4000 patients with multiple myeloma, revealed that patients in a real-world setting demonstrated worse progression-free and overall survival on six […]

SLE is a heterogeneous disease, which can cause many different manifestations and symptoms, and traditionally did not have many treatment options. However, the picture is changing, and clinical practice must change accordingly, to keep up with modern treatment options and to make the most of new drugs that can target key pathophysiological pathways. In line […]

Roughly 10% of fecal immunochemical tests (FIT) used for colorectal cancer (CRC) screening by a safety-net health system contained unsatisfactory samples that could not be processed. And fewer than half of patients with unacceptable FIT samples completed a follow-up test within 15 months, a large retrospective study finds. “The high prevalence of unsatisfactory FIT in […]

UKHSA is strongly encouraging eligible people from ethnic minority groups, particularly people from the Pakistani and black Caribbean ethnic groups and individuals living in more deprived areas, to book their flu and COVID-19 vaccines. This will protect them and their families against the heightened risks of these infections during winter. Data from UKHSA’s report on […]