Regenstrief Institute, the International Medical Informatics Association (IMIA), the International Academy of Health Sciences Informatics (IAHSI) and the American Medical Informatics Association (AMIA) are hosting a mini-summit at the AMIA 2023 Annual Symposium to address how informatics can help resolve health issues caused by climate change. The event will bring together national and international experts […]

PHILADELPHIA — Giving the SGLT-2 inhibitor dapagliflozin (Farxiga) to patients with acute myocardial infarction (MI) and impaired left ventricular systolic function but no diabetes or chronic heart failure significantly improved a composite of cardiovascular outcomes, a European registry-based randomized trial suggests. In presenting these results from the DAPA-MI trial, Stefan James, MD, of Uppsala University […]

Neurodegenerative diseases like Alzheimer’s and Parkinson’s can be associated to depression and anxiety. Dr. Sabine Krabbe, a neuroscientist at DZNE’s Bonn site, is receiving 1.2 million US dollars from the Chan Zuckerberg Initiative to understand the mechanisms involved in the onset of these syndromes. To this end, she aims to examine the function of the […]

TOPLINE: A combination of tocilizumab (Actemra) and 8 weeks of tapering prednisone was effective for inducing and maintaining disease remission in adults with giant cell arteritis (GCA). METHODOLOGY: In a single-center, single-arm, open-label pilot study, 30 adults (mean age, 73.7 years) with GCA received 162 mg of tocilizumab as a subcutaneous injection once a week for […]

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Mark Abbott, the Managing Director of Peak Proteins, about protein science and its significance in drug discovery.  Please can you introduce yourself and tell us what inspired your career in protein and cell science? I am Mark Abbott, the Managing Director of […]

Preoperative biopsy results in patients with esophageal adenocarcinoma (EAC) often misrepresent true tumor grade, according to a recent retrospective study. Inaccurate preoperative biopsy findings could mean that patients who are candidates for endoscopic resection (ER) are unnecessarily undergoing esophagectomy, a procedure with greater risks of morbidity and mortality, reported Ravi S. Shah, MD, of Cleveland Clinic, […]

A recent study published in the journal Nature Communications provides evidence of subcontinental admixture in people with European ancestry, in contrast to previous genetic association studies that recognize European ancestry populations as stratified and not as admixed.   Study: Unappreciated subcontinental admixture in Europeans and European Americans and implications for genetic epidemiology studies. Image Credit: Pixels Hunter […]

Popular new glucagon-like peptide 1 receptor agonists require some pre-procedure considerations but not necessarily discontinuation of the drugs to support the success of endoscopic procedures, according to a new Clinical Practice Update from the American Gastroenterological Association. Use of glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1 RAs) has been associated with delayed gastric emptying, which raises […]

A new report in the peer-reviewed journal Telemedicine and e-Health provides a review of the published literature on antibiotic prescribing and antibiotic stewardship in outpatient telemedicine. At least 28% of antibiotic use in outpatient settings is unnecessary, contributing to excess costs, adverse drug events, and antibiotic resistance. Antibiotic stewardship, as provided for in a framework […]

Phytoestrogens show potential as a treatment for menopausal women with late-onset asthma that may relieve symptoms of both conditions, according to a new review. Fluctuations in female sex steroid hormones during menstrual periods have been linked to asthma exacerbations, and the absence of these hormones during childhood and menopause has been associated with fewer and less […]