Once-daily treatment with the selective aldosterone synthase inhibitor lorundrostat (Mineralys Therapeutics) safely and significantly reduced blood pressure in adults with uncontrolled hypertension in a phase 2 randomized controlled trial. Eight weeks after adding lorundrostat (50 mg or 100 mg once daily) or placebo to background therapy, the medication lowered seated automated office systolic blood pressure […]

In a recent study published in Nature Communications, researchers described the detection of a human interleukin-1β (hIL-1β) antagonist with low molecular weight (LMW) that disrupts interactions with the interleukin-1 receptor, type I (IL-1R1) receptor. Study: Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β. Image Credit: Jarun Ontakrai/Shutterstock.com Background Oral antagonists […]

By the end of 2021, Anuj Peddada, MD, had hit a wall. He couldn’t sleep, couldn’t concentrate, erupted in anger and felt isolated personally and professionally. To temper pandemic-driven pressures, the Colorado radiation oncologist took an 8-week stress management and resiliency course, but the feelings kept creeping back. Still, Peddada, in his own private practice, […]

New research led by Queen’s University Belfast has made a breakthrough in the field of microbiology, which could lead to the development of new treatments for people with compromised immune systems, such as those with cystic fibrosis. Image Credit: Queen’s University Belfast To conduct their study the researchers looked at the bacterium Achromobacter which can […]

Anxiety and depression are prevalent in patients with gastroesophageal reflux disease (GERD), according to a large-scale analysis that also found evidence for a possible underlying causal link between GERD and the common psychiatric conditions. In a systematic review and meta-analysis, researchers found that anxiety and depressive symptoms were more than twice as likely in patients with […]

Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings, which were reported in the September 7 issue of Nature Structural & Molecular Biology [DOI: 10.1038/s41594-023-01085-6], could lead to the development of […]

TOPLINE: Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for precancerous colorectal adenomatous polyps in men and women, according to results of a large study. METHODOLOGY: Researchers conducted a retrospective review of the medical records of adults who underwent abdominal ultrasound and colonoscopy at a single hospital in China from January 2018 to […]

In a recent study published in PLOS Digital Health, researchers investigated the complexity of polypharmacy and whether frequent dose adjustments were required for co-medications and drug pairs in hospital settings. Study: Study explores association between polypharmacy and dose adjustments. Image Credit:solarseven/Shutterstock.com Polypharmacy, a growing concern in healthcare due to multimorbid, aging populations, increases the risk […]

AMSTERDAM — A short course of the interleukin-1 receptor antagonist, anakinra, appeared safe but did not reduce complications of acute myocarditis in the ARAMIS trial. The trial was presented at the European Society of Cardiology (ESC) Congress 2023 held recently in Amsterdam, the Netherlands. Lead investigator, Mathieu Kerneis, MD, Pitie Salpetriere APHP University Hospital, Paris, […]

In a recent review published in Cell, a group of authors delved into the complexities of menopause, assessed its global impacts on health, and evaluated the effectiveness and safety of current treatments, emphasizing the importance of further research. Study: Menopause—Biology, consequences, supportive care, and therapeutic options. Image Credit: AlesiaKan/Shutterstock.com Background Menopause, commonly experienced by women […]