NEW YORK – Patients with chronic plaque psoriasis face a nearly twofold increased risk of nonalcoholic fatty liver disease (NAFLD), and the risk climbs higher in those with more severe skin involvement – and probably in those with psoriatic arthritis (PsA) as well, according to a systematic review and meta-analysis presented at the annual meeting […]
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Anti-SARS-CoV-2 nucleocapsid antibodies and pre-existing lung ailments could also be unbiased predictors of lengthy COVID
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In a recent study published in the Journal of Clinical Investigation, a team of Stanford researchers evaluated the incidence of long coronavirus disease (long COVID) in a demographically diverse population with different disease severities to inform clinicians and future vaccine development strategies. Study: Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post–COVID-19 syndrome. […]
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NEW YORK — Gene therapy could provide an effective alternative for controlling severe diabetic retinopathy, researchers say. The therapy induces cells to make an antivascular endothelial growth factor (VEGF) molecule similar to ranibizumab, said Charles Wykoff, MD, PhD, deputy chair of ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Texas. “From an efficacy perspective, we’re seeing […]
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Scientists discover guanine-specific pocket in SARS-CoV-2 nucleocapsid protein of therapeutic worth in opposition to a number of coronaviruses
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In a recent study published in Communications Biology, researchers studied open and closed conformations of the C-terminal of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein termed the NCTD. Additionally, they derived the crystal structure of the NCTD in complex with guanine triphosphate (GTP). Study: Identification of a guanine-specific pocket in the protein […]