Category Archives: Articles

SAN DIEGO — In published trials, both an IL-17 inhibitor and an IL-23 inhibitor achieved impressive rates of clear or almost clear responses in patients with moderate to severe plaque psoriasis, but late-breaker data presented at the annual American Academy of Dermatology meeting show that these types of responses are sustained for as long as […]

The body’s inability to produce enough insulin or use it effectively often results in type 2 diabetes (T2D), a chronic disease affecting hundreds of millions of people around the globe. Disease management is crucial to avoid negative long-term outcomes, such as limb amputation or heart disease. To counteract adverse consequences, it is crucial that patients […]

SAN DIEGO — New guidelines for cutaneous melanoma have been issued by the National Comprehensive Cancer Network (NCCN), creating some new standards of practice that extend a slow divergence from the last set of detailed recommendations released by the American Academy of Dermatology (AAD) in 2019. Based on the constantly evolving science that drives guidelines, […]

Helicases are enzymes that unwind DNA and RNA. They’re central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.  Now, new research provides a powerful platform for designing covalent inhibitors tailored to target helicases. The paper, published in the Journal of the American Chemical Society, describes how researchers […]

Disappointing phase 3 trial results of a drug approved for the treatment of amyotrophic lateral sclerosis (ALS) may prompt the manufacturer to voluntarily pull it from the market, the company announced today.  After 48 weeks, sodium phenylbutyrate-taurursodiol (Relyvrio) offered no significant improvements compared to placebo, failing to meet the randomized controlled trial’s primary or secondary […]

In a recent review published in the journal PNAS, researchers explore non-viral and cell-specific clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) delivery methods and emphasize their advantages for research and gene therapy applications. Study: Targeted nonviral delivery of genome editors in vivo. Image Credit: Catalin Rusnac / Shutterstock.com Improving the delivery of CRISPR-Cas enzymes CRISPR-Cas […]

WEST PALM BEACH, FLORIDA — When evaluated at 3 or 12 months, serum neurofilament light chain (sNfL) levels were predictive of new or enlarging T2 lesions in patients with multiple sclerosis (MS) regardless of treatment assignment, new sub-study data from the ASCLEPIOS I/II trials showed. The findings were presented at the 2024 Americas Committee for […]

More than 70% of American Indian young adults aged 20-39 and 50% of American Indian teens have cholesterol levels or elevated fat in the blood that put them at risk for cardiovascular disease, suggests a study supported by the National Institutes of Health. In some cases, these levels -; specifically high low-density lipoprotein (LDL) cholesterol, […]

The US Food and Drug Administration (FDA) has cleared Dexcom’s Stelo Glucose Biosensor System as the first over-the-counter continuous glucose monitoring (CGM) system. Unlike Dexcom’s G6 and G7 CGM systems, the Stelo is intended for adults with or without diabetes who don’t use insulin. “Importantly, this system is not for individuals with problematic hypoglycemia as […]

For years, scientists have expressed concern about potential adverse health effects of excessive exposure to short wavelength light (SWL), which includes the “blue light” from smartphones, laptops, and tablets. However, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has identified a lack of consensus among public health officials about whether SWL from artificial sources disrupts […]