SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies. Woman sitting on sofa in the dark, placing a hand to her forehead. Image Credit: Annie Spratt […]
NATIONAL HARBOR, MARYLAND — Rates of maternal morbidity in individuals with placenta accreta were similar with alternative strategies to cesarean hysterectomy regardless of the severity of the condition, based on data from 60 individuals. Currently, the recommended management strategy for placenta accreta spectrum (PAS) is a cesarean hysterectomy, but data are lacking on alternative strategies, […]
A new study led by investigators from Mass General Brigham demonstrated the use of deep brain stimulation (DBS) to map a ‘human dysfunctome’ -; a collection of dysfunctional brain circuits associated with different disorders. The team identified optimal networks to target in the frontal cortex that could be used for treating Parkinson’s disease, dystonia, obsessive […]
TOPLINE: Women with steatotic liver disease (SLD) related to alcohol consumption are at greater risk of mortality than men with the same condition, new research suggested. METHODOLOGY: Researchers analyzed data from the US National Health and Nutrition Examination Survey III (NHANES III, 1988-1994), which included standardized ultrasonographic measures of hepatic steatosis, assessment of cardiometabolic risk […]
Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs), particularly endocrine toxicity, that can severely compromise patient well-being. Existing research has often been limited in scope and has not provided comprehensive safety profiles across the diverse range of […]
Patients with Cushing disease have an increased risk for new-onset autoimmune disease in the 3 years after surgical remission, according to a new retrospective study published on February 20 in Annals of Internal Medicine. Outcomes for patients with Cushing disease were compared against those with nonfunctioning pituitary adenomas (NFPAs). New-onset autoimmune disease occurred in 10.4% […]
An innovative computer model of a human lung is helping scientists simulate, for the first time, how a burst of radiation interacts with the organ on a cell-by-cell level. This research, carried out at the University of Surrey and GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, could lead to more targeted treatments for cancer and reduce the […]
Loneliness is no longer just a personal struggle; it’s a silent epidemic. The US surgeon general has compared it with smoking, claiming it’s as harmful as up to 15 cigarettes a day. The toll on health is staggering, from cardiovascular risks to mental health struggles. It’s time to face the brutal truth: Loneliness isn’t just […]
In order to monitor and operationalize food system shifts, it is essential to understand how diets affect health and the environment. A recent Nature Food study put forward a health–environment efficiency indicator to evaluate how diets have historically supported healthy lives, environmental pollution, and resource consumption across 195 countries. Study: Health–environment efficiency of diets shows nonlinear trends over […]
The US Food and Drug Administration (FDA) has approved lifileucel (Amtagvi, Iovance Biotherapeutics, Inc.) for the treatment of certain adults with unresectable or metastatic melanoma, marking the first approval of a cellular therapy in the solid tumor setting. Specifically, the tumor-derived autologous T-cell immunotherapy is indicated for adult patients previously treated with a programmed cell […]